In diverse conditions intrinsic chromatin condensates have liquid Biology Diagrams Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this process has left its molecular mechanism unclear. A cascade of histone modifications induces chromatin condensation in mitosis. Science 343 , 77-80 (2014). Article ADS CAS PubMed Google Scholar Learn about the process of compacting and reorganizing DNA during cell division, which is crucial for the accurate transmission of genetic material. Explore the molecular mechanisms, players, and effects of chromatin condensation in various contexts, such as apoptosis, oocytes, and drug metabolism.
Different pathways of chromatin condensation in mitosis and hyperosmolar condensation. A) Histone H3 is modified by phosphorylation at serine 10 during mitosis and was detected in formaldehyde-fixed HeLa H2B-GFP cells using anti-phospho H3S10-specific antibodies.Top panel: phosphorylated histone H3 signal (red) colocalizes with histone H2B-GFP-labeled chromosomes in the mitotic cell, but it is
Mechanism of phase condensation for chromosome architecture and ... Biology Diagrams
Chromatin-binding proteins can regulate chromosome organization and chromosome condensation by phase separation. Histone H1 promotes the phase separation of chromatin, which increases the concentration of nucleosomes within droplets and decreases droplet dynamics, consistent with the role of histone H1 as a repressive chromatin architectural
Chromatin Condensation. Electron micrograph images reveal that each chromatid is arranged into loops of chromatin, which emanate from a central scaffolding. Condensins work to coil the two DNA molecules, using the energy from ATP hydrolysis. 5 The result is the two sister chromatids associated with the mitotic chromosome. a Representative V DLS, D *, and chromatin condensation maps along with confocal fluorescence images of chromatin (H2B-mCherry) in cell nuclei under different chemical treatments that modify the
Nested Irreducible Complexity Biology Diagrams
Condensation of chromatin into sturdy chromosomes is also necessary to establish proper physical properties. Chromosomes must be stiff, resilient, and elastic enough to withstand forces coming from pulling microtubules and cytoplasmic drags during mitosis to prevent damage and breaks caused by external tensions.
